- Social Event at Ithaca Beer Co
- Taylor recognized with young investigator award at ICCBMT
- Ganesan and Patel win ELI Undergraduate Research Awards
- Hemmerling to Present at the Orthopedic Research Society Annual Meeting, February 2-5
- Hemmerling wins ELI Undergraduate Research Award
- Mileti to Present at SciX Conference, October 21-26
- Donnelly to Present at ASBMR annual meeting, September 28-October 1
- Mileti receives SAS Undergraduate Student Award
- Lloyd AA, Luengo EA, Donnelly E. Atypical fracture with long-term bisphosphonate therapy is associated with altered cortical composition and reduced fracture resistance. PNAS. 2017
- Palomino, Taylor, Lloyd to present at ORS Upstate meeting, July 27-28
- Hunt recognized with young investigator award at ICCBMT meeting
- Taylor EA, Lloyd AA, Salazar-Lara C, Donnelly E. Raman and Fourier Transform Infrared (FT-IR) Mineral to Matrix Ratios Correlate with Physical Chemical Properties of Model Compounds and Native Bone Tissue. Applied Spectroscopy. 2017
- Palomino to present at ORS annual meeting, March 19-22
- DeLucia and Burke to present at Cornell Undergraduate Research Board Fall Poster Forum, November 16
- Heather B. Hunt, Eve Donnelly. Bone Quality Assessment Techniques: Geometric, Compositional, and Mechanical Characterization from Macroscale to Nanoscale. Clinic Rev Bone Miner Metab. 2016
- ASBMR atypical fractures award bisphosphonate bone collagen conference diabetes Engineering Learning Initiatives Undergraduate Research Award fellowship FTIR imaging fun graduate student grant invited talk material properties mechanical behavior mechanical properties MRS multiscale nanomechanical properties NIAMS NIH NSF osteoporosis publication sledding student trabecular bone Type II diabetes undergraduate winter
PhD student Erik Taylor was awarded a young investigator award at the International Conference on the Chemistry and Biology of Mineralized Tissues in Quebec, Canada to present his abstract entitled, “Raman and FTIR bone mineral crystallinity and carbonate content differentially relate to analytical physical chemical measures”.
Sandhya Ganesan and Himani Patel were awarded Engineering Learning Initiatives Research Awards for their proposals, “Characterization of bone compositional properties in a mouse model of brittle bone disease” and “Effects of Type 2 Diabetes Mellitus on bone tissue composition in men”, respectively. Congrats Sandhya and Himani!
Kimberly Hemmerling is presenting a talk entitled “Corrosion In Retrieved Metal Liners Of Modular Dual Mobility Systems For THA” at the ORS annual meeting in Austin, Texas on Saturday, February 2nd.
Kimberly Hemmerling was awarded an Engineering Learning Initiatives Undergraduate Research Award for her proposal, “Microstructural characterization of human of cervical tissue throughout pregnancy.” The ELI grant provides support for her senior thesis. Congratulations Kim!
Cassidy Mileti will present her poster entitled, “Raman and FTIR spectroscopic measures of crystallinity differentially assess crystal size and stoichiometric perfection in hydroxyapatite” at the Society for Applied Spectroscopy Student Poster Session.
Eve Donnelly will present an oral presentation of Pablo Palomino’s research entitled “Advanced glycation endproduct content is increased in cortical bone of the femoral neck in men with type 2 diabetes mellitus.”
Cassidy Mileti was recognized by the Society for Applied Spectroscopy for her study of carbonate-substituted apatites and native bone tissue by FT-IR and Raman spectroscopy, as well as x-ray diffraction, developing FT-IR acid phosphate intensity ratio to further our basic understanding of the interactions between anionic substitutions in synthetic apatites and native bone tissue.
Lloyd AA, Luengo EA, Donnelly E. Atypical fracture with long-term bisphosphonate therapy is associated with altered cortical composition and reduced fracture resistance. PNAS. 2017
Bisphosphonates are the most widely prescribed pharmacologic treatment for
osteoporosis and reduce fracture risk in postmenopausal women by up to 50%. However, in the past decade these drugs have been associated with atypical femoral fractures (AFFs), rare fractures with a transverse, brittle morphology. The unusual fracture morphology suggests that bisphosphonate treatment may impair toughening mechanisms in cortical bone. The objective of this study was to compare the compositional and mechanical properties of bone biopsies from bisphosphonate-treated patients with AFFs to those from patients with typical osteoporotic fractures with and without bisphosphonate treatment. Biopsies of proximal femoral cortical bone adjacent to the fracture site were obtained from postmenopausal women during fracture repair surgery (fracture groups, n= 33) or total hip arthroplasty (nonfracture groups, n = 17). Patients were allocated to five groups based on fracture morphology and history of bisphosphonate treatment [+BIS Atypical: n = 12, BIS duration: 8.2 (3.0) y; +BIS Typical: n = 10, 7.7 (5.0) y; +BIS Nonfx: n = 5, 6.4 (3.5) y; −BIS Typical: n = 11; −BIS Nonfx: n = 12]. Vibrational spectroscopy and nanoindentation showed that tissue from bisphosphonate-treated women with atypical fractures was harder and more mineralized than that from bisphosphonate-treated women with typical osteoporotic fractures. In addition, fracture mechanics measurements showed that tissue from patients treated with bisphosphonates had deficits in fracture toughness, with lower crack-initiation toughness and less crack deflection at osteonal boundaries than that of bisphosphonate-naïve patients. Together, these results suggest a deficit in intrinsic and extrinsic toughening mechanisms, which contribute to AFFs in patients treated with long-term bisphosphonates.
Pablo Palomino will present his poster entitled, “Advanced glycation endproducts impair cortical bone tissue quality in men with type 2 diabetes mellitus.” Erik Taylor will present his power entitled, “Raman and FTIR bone mineral crystallinity and carbonate content correlate with physical chemical measures.” Ashley Lloyd will present her poster entitled, “Multiscale characterization of material properties of cortical tissue from patients with atypical femoral fractures.”